Inside. Adults: The usual dose is 250 mg 2 times / day for 7 days, if necessary, the dose may be increased to 500 mg 2 times / day for up to 14 days in severe infections.
Children older than 12 years: the dosing regimen as adults.
To treat duodenal ulcers caused by H. pylori (for adults):
Scheme triple therapy (days 1-14): clarithromycin 500 mg 2 times / day; lansoprazole 30 mg 2 times / day; 1000 mg amoxycillin 2 times / day.
Scheme triple treatment (7 days): clarithromycin 500 mg 2 times / day; lansoprazole 30 mg 2 times / day; metronidazole 400 mg 2 times / day.
Driving triple therapy (7 days): klarigromitsin 500 mg 2 times / day; omeprazole 40 mg / day; amoxicillin 1000 mg 2 times / day or 400 mg metronidazole two times / day.
Driving triple therapy (10 days): Clarithromycin 500 mg 2 times / day appointed with amoxicillin 100 mg 2 times / day and omeprazole 20 mg / day.
Driving dual therapy (14 days): Clarithromycin 500 mg 3 times / day, 40 mg of omeprazole into 1 time / day.
usually does not require dose adjustment With the defeat of renal function except in patients with severe renal impairment (creatinine clearance <30 mL / min), but the total daily dose should be reduced by half if necessary, ie 250 mg 1 time / day or 250 mg 2 times / day in more severe infections.
At the same time taking ritonavir to patients with impaired renal function Dosage adjustment is recommended in the following way: for patients with CC 30-60 ml / min the dose of clarithromycin should be reduced by 50%. For patients with CC less than 30 ml / min clarithromycin dose should be reduced by 75%. In a joint application of clarithromycin and ritonavir should not be used in excess of the dose of clarithromycin 1 g / day.